Abstract
The proteolytic activity of serum bound with α 2-macroglobulin has been determined by means of a synthetic arginine amide substrate in a wide variety of diseases. Normal activity was found in patients with no disorders of hemostasis but suffering from various cardiovascular and bronchopulmonary diseases, cholecystitis, acute pancreatitis, diseases of the digestive system, and diseases of the kidneys. A significant decrease in the serum activity studied was observed in patients with blood coagulation disorders, including deficiency of vitamin K-dependent factors caused either by liver disease or coumarin drugs, thrombocytopenias and hemophilia. In the recalcified plasma of these patients both the generation of the proteolytic activity bound with α 2-macroglobulin and of thrombin were depressed. This indicates that the reduced generation of the proteolytic activity bound with α 2-macroglobulin in clotting blood leads to a decrease of this activity in the sera of patients with certain blood coagulation disorders. Determination of the proteolytic activity of serum bound with α 2-macroglobulin may be used to test the clotting function of blood, and may provide useful information in clinical conditions leading to impaired thrombin formation during blood coagulation.
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