Abstract
Silver nanoparticles (AgNPs) are being used extensively for biomedical purposes regarding to their broad antimicrobial activity, however their toxicity has been addressed in only few studies. In the present study, we aimed to prepare and characterize AgNPs, investigate their adverse effect on liver and kidney functions, and also elucidate the hepato-nephro protective ability of tannic acid in male rats. The obtained results showed that AgNPs caused oxidative stress throughout the induction of thiobarbituric acid-reactive substances (TBARS) and the reduction of the activities of antioxidant enzymes (GST, SOD, CAT, GPx) and the levels of glutathione. Hepatic markers enzymes (AST, ALT, ALP, ACP, LDH and GGT), total bilirubin, urea, creatinine and lipid profile were increased, while hematological parameters were decreased. Histopathological investigations indicated marked degeneration of hepatocytes, endothelial cells of renal which with its role has confirmed the hepatotoxicity and nephrotoxicity induced by AgNPs. The presence of tannic acid along with AgNPs showed obvious improvements in the injured liver and kidney tissues. The protective effect of tannic acid against the toxicity of AgNPs might be due to its antioxidant properties and scavenging abilities against active free radicals.
Highlights
A rising research has been done on metal nanoparticulates due to their excellent catalytic, optical, electrical, magnetic, antimicrobial and other physical and chemical characteristics; those are completely different from their bulk size
Silver nanoparticles were prepared by chemical reduction method according to Fang et al [22], by aqueous AgNO3 reducing with sodium citrate at boiling temperature
UV-Vis spectroscopy is a method used to examine nanoparticles production based on their optical characteristic
Summary
A rising research has been done on metal nanoparticulates due to their excellent catalytic, optical, electrical, magnetic, antimicrobial and other physical and chemical characteristics; those are completely different from their bulk size. Silver nanoparticles have been used in a wide range in consumer products especially air and water filters due to their antiseptic properties, towels, clothes, paints and cleansers for surface cleansing, as well as many applications in biotechnology and life sciences [5]. They have been used for the treatment of many diseases such as breast cancer, leukemia and different carcinomas [6]. Regular consumption and direct contact with products like medications and food containing silver nanoparticles represent a sustainable source of AgNPs which when emitted to the environment might produce a substantial contamination hazard [7] and a prospective risk to human health [8]
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