Abstract
Neural tube defects(NTD)are a common congenital malformations in humans leading to infant mortality or severe disability.The etiology of NTD is complicated, with both environmentaland genetic contributions.It has been found that the protein markers associated with NTD are mainly maternal serum alpha fetoprotein, amniotic fluid alpha fetoprotein and amniotic fluid glial fibrillary acidic protein.This article reviews the protein biomarks related with NTD. Key words: Neural tube defects; Maternal serum alpha fetoprotein; Amniotic fluid alpha fetoprotein; Amniotic fluid glial fibrillary acidic protein; S100 protein
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