Abstract
Purpose: It is now well recognized that osteoarthritis (OA) synovial membrane presents inflammatory components characterized by cellular proliferation, sub-intimal leukocytes infiltration and neovascularization. In this study, proteomics LC-MS/MS was applied to knee synovitis from patients with OA, chronic pyrophosphate arthropathy (CPPA) and rheumatoid arthritis (RA). The aim of this work was to provide evidence that similar inflammatory mechanisms in synovitis exist among the three pathologies presenting a histological inflammatory gradient.
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