Abstract
Time-resolved FT-IR. difference spectroscopy has recently been established as a new biophysical tool for the investigation of molecular reaction mechanisms of proteins at the atomic level.1 Complementary to NMR spectroscopy and x-ray structure analysis, which provide the static protein ground state structure with atomic resolution, time-resolved FT-IR difference spectroscopy monitors the dynamics of proteins at the atomic level. Although infrared spectroscopy is a classical method of analytical and structural investigations 2, it can also provide valuable insight into the mechanisms of chemical reactions. Especially timeresolved Fourier-Transform-Infrared-difference-spectroscopy has recently proved itself as a powerful new method for studies of molecular reaction mechanisms of large proteins up to 120000 Dalton and time resolution up to nanoseconds.
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