Abstract
AbstractIn the search for new natural PTP1B inhibitory compounds from medicinal plants, two 9,10âanthraquinones were isolated and structurally identified as physcion (1) and emodin (2) from the alcoholic extract of the root of Polygonum cuspidatum. Chemical structures of these isolates were identified by interpretation of spectroscopic data (1H, 13C NMR and MS) as well as comparing with reported literatures. Compounds 1â2 possessed inhibitory activity on PTP1B enzyme with IC50 values of 26.1 ± 0.7 and 13.3 ± 0.4 ÎŒM, respectively. Ursolic acid was used as positive control showing an IC50 value of 3.5 ± 0.2 ÎŒM in this assay. This result reveals that these 9,10âanthraquinones might be considered as new natural compounds for development of antidiabetic agents.
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