Abstract
The role of protein tyrosine kinases (PTK) in TNFα secretion by human monocytes was investigated in this report. We showed that an immunomodulator such as Nocardia lysozyme digest (NLD) and a particulate agonist, zymosan, stimulated an increase in tyrosine phosphorylation of several endogenous substrates including 53–56 kDa protein which was the predominant phosphoprotein. In addition, NLD and zymosan induced TNFα secretion which was impaired by a PTK inhibitor, tyrphostin. We suggest that a cascade of kinases including PTK is involved in NLD and zymosan signalling.
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