Protein targets in red complex pathogens for catechin.

T Cibikkarthik,

doi:10.6026/973206300171105

Abstract

The development of antimicrobial drug resistance has encouraged scientists to develop alternate methods to combat infectious pathogens associated with dental diseases. Therefore, it is of interest to predict interactions for catechin (a plant derived compound) with protein targets in the red complex pathogens using computer aided network tools. However, in vitro and in vivo studies are warranted to confirm the antimicrobial effect of catechin (gallocatechin, epicatechin, epigallactocatechin (EGC) and gallolyl catechins) on the dental pathogens.

Highlights

Drug resistance to pathogens has reached alarming numbers in recent times
Strains used in the study: The strains of red complex pathogens sich as Porphyromonas gingivalis ATCC 33277, Treponema denticola ATCC 35405 and Tannerella forsythia ATCC 43037 available in the STITCH database were selected for the analysis (Figure 1, Table 1)
Catechin is a major component of green tea known for its antioxidant, anti-inflammatory, anti-proliferative activities

Summary

Protein targets in red complex pathogens for catechin

Received June 17, 2021; Revised September 27, 2021; Accepted September 27, 2021, Published December 31, 2021. The authors undertake that they are not associated with any other third party (governmental or non-governmental agencies) linking with any form of unethical issues connecting to this publication. The authors declare that they are not withholding any information that is misleading to the publisher in regard to this article. Author responsibility: The authors are responsible for the content of this article. The editorial and the publisher have taken reasonable steps to check the content of the article in accordance to publishing ethics with adequate peer reviews deposited at PUBLONS. This article is part of a special issue on Dental Biology Abstract: The development of antimicrobial drug resistance has encouraged scientists to develop alternate methods to combat infectious pathogens associated with dental diseases.

Background

Materials and Methods

Tannerella forsythia

Results and Discussion

Conclusion