Protein Synthesis and the Genetic Code in Subcellular Systems Derived from Normal and Neoplastic Animal and Human Tissues.

Abstract

s1 November 1965Protein Synthesis and the Genetic Code in Subcellular Systems Derived from Normal and Neoplastic Animal and Human Tissues.Manuel Ochoa Jr., M.D., I. B. Weinstein, M.D.Manuel Ochoa Jr., M.D.Search for more papers by this author, I. B. Weinstein, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-5-917_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe escape from host control characteristic of tumor cells may reflect changes in the mechanism of protein synthesis or alterations in the genetic code. The present study compares normal and neoplastic cells with respect to amino acid coding and the biochemical steps in protein synthesis.As inEscherichia coli, protein synthesis by extracts from human chronic lymphocytic leukemia, mouse L1210 leukemia, a human plasma cell tumor, the rat MtT/W5 mammosomatotropic pituitary tumor, rabbit reticulocytes, and normal rat liver could be redirected by synthetic messenger ribonucleic acid (RNA) (mRNA). A group of synthetic mRNAs, differing in their base compositions, have been... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByTHE ROLE OF DIABETOGENIC HYPERINSULINISM IN THE PATHOGENESIS OF PROSTATIC HYPERPLASIA AND MALIGNANCY* 1 November 1965Volume 63, Issue 5Page: 917-918KeywordsCellsGeneticsLiverLymphocytic leukemiaPituitary tumorsPlasma cellsProtein synthesisRNARabbitsReticulocytes Issue Published: 1 November 1965 PDF DownloadLoading ...