Abstract
This study aimed to pursue the correlation between essential/nonessential gene and protein subcellular localization. The protein sequences of the essential/nonessential genes of 28 prokaryotes in Database of Essential Genes were analyzed by PSORTb3.0. Results show that proteins of essential genes locate in cytoplasm with relatively high percentage, i.e., in the range of 40% to 55%. Percentages of the proteins of essential genes locate in cytoplasma membrane are lower than that of nonessential genes, which mostly are about 15%. However, the values of proteins of nonessential genes are mostly about 20%, and that of Gram-positive bacteria are close to 30%. The distributions of protein subcellular localization of the essential/nonessential genes are different evidently. This could be used for classification of essential and nonessential genes.
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