Abstract
1.1. Estrogen treatment causes a simultaneous increase in the amounts of circulating vitellogenin and total liver RNA in sexually mature male and nonvitellogenic female flounders.2.2. In nature, initiation of ovarian growth in female flounders is characterized by marked increases in the amounts of circulating vitellogenin and of total DNA and RNA in the liver.3.3. RNA and vitellogenin reach maximum level in December, when ovarian growth is rapid and the liver weights maximal.4.4. A linear relationship exists between liver wet weight and total hepatic DNA with a correlation coefficient of 0.84.
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