Abstract
Objectives To evaluate oxidative stress and the extent of oxidation of plasma proteins in type 2 diabetic patients. Design and methods Study was carried out on blood from 31 diabetic patients of both sexes (mean age = 58 ± 7; duration of diabetes 12 ± 5 years) and healthy age and sex matched normal subjects. Biomarkers of protein oxidation; plasma protein carbonyls (PCO), advanced oxidation protein products (AOPPs) and –SH group and free radical scavenging capacity of plasma was measured. Results PCO and AOPPS levels were significantly ( P < 0.005) higher in diabetic patients in comparison to healthy volunteers. Reduced free radical scavenging capacity ( P < 0.001) and –SH group ( P < 0.05) was observed in plasma of type 2 diabetic patients. Conclusions Our data suggest that diabetics are susceptible to protein oxidation. Oxidative modulation of proteins due to reduced radical scavenging activity of plasma patients may be one of the reasons of altered physiological processes in type 2 diabetic patients.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.