Abstract
Structural proteomics based on synchrotron radiation [1] and label-free microarrays [2] have recently provided the nanotechnological framework for significant advances in medical diagnosis and therapy [3,4], laying down, at the nanoscale, level the foundation and definition for functional and structural proteomics in nanomedicine [5]. At the same time, with the introduction of new matrices from organic, inorganic and biological nanocomposites [6] many applications in sensor technology to detect biological molecules of medical and environmental relevance have emerged with significantly more selectivity and sensitivity than what had been obtainable so far [7,8]. Of particular interest are the sensor developments originating from the combination of modern functional proteomics [2–4] with quartz crystal microbalance, exploiting both frequency shifts (Df) and dissipation factor (D) for the simultaneous evaluation of mass variation (Sauerbrey equation) and viscoelasticity at the nanoscale [9].
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