Protein Micropatterns: Multiphoton 3D Microprinting of Protein Micropatterns with Spatially Controlled Heterogeneity – A Platform for Single Cell Matrix Niche Studies (Adv. Biosys. 8/2018)

Abstract

A cell niche is a complex microenvironment that cells are exposed to in tissues. In article number 1800053, Barbara Pui Chan and co-workers use multiphoton micro-printing technology to create protein micro-patterns with independently and spatially controlled matrix and mechanical properties. Human mesenchymal stem cells cultured on a protein micro-niche spread towards selective protein islands with different extracellular matrices. This platform contributes to highthroughput screening of cell niche factors for biomimetic scaffold design.