Protein Microarrays in Proteome-wide Applications

Abstract

Proteomics aims at understanding of protein status under certain physiological or diseased conditions in a large scale. Protein microarray technology has emerged as a promising approach for a wide variety of applications for scientific and clinical research on a whole-proteome scale. Herein, the aim of this review is to summarize the most recent developments in the applications of protein microarrays for biomarker profiling, enzyme substrate profiling, small molecule profiling, protein-protein interaction profiling, and antibody specificity profiling.