Abstract
Abstract The interaction between alveolar macrophages and lymphocytes may alter the establishment of pulmonary infection with Myco-bacterium tuberculosis. Studies with a guinea pig model of pulmonary tuberculosis have demonstrated that chronic, moderate protein deficiency has a detrimental impact on disease resistance and cell-mediated immune responses, including mitogen and antigen-induced lympho-proliferation. Resident alveolar macrophages (AM) in humans and rodents suppress lymphoproliferation by producing inhibitors which include nitric oxide (NO). The effect of dietary protein deficiency on the interaction between guinea pig AM and concanavalin-A (ConA)-induced autologous splenocytes was quantified in co-culture. The AM of normally-nourished, high protein (HP) guinea pigs inhibited the ConA-in-duced proliferation of splenocytes at AM: splenocyte ratios of 1:4 or higher. However, the AM of malnourished, low protein (LP) guinea pigs inhibited the proliferation of splenocytes at AM: splenocyte ratios of...
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