Abstract
S1-S4 voltage-sensing domains in voltage-activated ion channels control opening and closing of an associated pore domain. Electrophysiology experiments suggest that the transition of S1-S4 domains from resting to activated conformations is dependent on annular lipids. For example, experiments on the archaebacterial KvAP channel show that the voltage-activation relation for the channel shifts to depolarized voltages in the presence of lipids with positively charged head-groups (Schmidt, D., 2006).
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