Abstract
Treatment of intact adipocytes with the autoregulatory PKC pseudosubstrate PKC(19–31) inhibited insulin-stimulated hexose uptake and lipogenesis, with no effect on basal values. The effect was dose-dependent with respective IC 10 values of 30 μM and 600 μM for insulin-stimulated hexose uptake in electroporated and intact adipocytes. These studies indicate that PKC may play a role in the mediation of insulin action in adipocytes.
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