Abstract
Increased serotonin 2A (5-HT 2A) receptors have been reported in the postmortem brain of suicide victims. To examine if this increase is associated with the dysregulation of postreceptor sites in the signaling cascade, we determined [ 3H]phorbol dibutyrate (PDBU) binding to protein kinase C (PKC) in postmortem brain samples (Brodmann's areas 8 and 9) obtained from teenage suicide victims and control subjects. [ 3H]PDBU binding to PKC was determined in membranal and cytosolic fractions. We observed that B max of [ 3H]PDBU binding sites was significantly decreased in both membranal and cytosolic fractions in brain samples from Brodmann's areas 8–9 compared to matched controls. These results thus suggest that PKC may play a role in the pathophysiology of suicidal behavior.
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