Abstract
Taurine is one of the most abundant free amino acids comprising 38% and 18% of the total free amino acid pool in human duodenal and colonic mucosa, respectively1. Recent observations have demonstrated that serum and intestinal taurine concentrations were lower in patients with cancer2, trauma3, surgery4 and critical illnesses5 compared to healthy controls. These results postulate the possibility that intestinal taurine absorption might be impaired in such stressed conditions. Taurine transport across the intestinal epithelium plays an important role in the regulation of taurine homeostasis in neonates and adults particularly under diverse stressed conditions6. The brush border membrane of intestinal mucosal cells express the Na+- and Cl--dependent taurine transporter (TAUT) responsible for the active absorption of taurine across the epithelium. TAUT activity in the intestinal epithelium is known to be regulated in response to changes in the availability of dietary sulfur amino acids6,7.
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