Abstract
Catheter-associated urinary tract infections (CAUTIs) caused by biofilms on indwelling medical devices are the most common type of nosocomial infections, a major health concern due to complications and frequent recurrence. The infections are most often caused by Escherichia coli. Curli are proteinaceous components of a complex extracellular matrix produced by various strains of Enterobacteriaceae. Curli fibers are involved with adhesion to surfaces, cell aggregation and biofilm formation. Therefore, it is of interest to study the protein interactions in curli biogenesis, identifying proteins involved in curli biogenesis, the interactions and development of a combinatorial library of novel lead molecules against biofilm formation by Escherichia coli. Targeting the CsgG protein of Escherichia coli could provide new treatment modalities to fight CAUTIs, better. This study may also help study infections caused by various strains of Enterobacteriaceae, in general.
Highlights
A biofilm is made up of a polysaccharide matrix embedded with microbial cells that associate with a surface irreversibly [1,2]
It is of interest to study curli biogenesis and the protein-protein interactions involved in the biofilm formation
Among Urinary tract infection (UTI) acquired in the hospital, approximately 80% were estimated to be associated with urinary catheters [9]
Summary
A biofilm is made up of a polysaccharide matrix embedded with microbial cells that associate with a surface irreversibly [1,2]. These curli proteins are responsible for surface adhesion, aggregation of cells and formation of biofilms [7]. It is of interest to study curli biogenesis and the protein-protein interactions involved in the biofilm formation. We further use a combinatorial library of lead molecules derived from existing literature of phyto chemicals to describe hits with proven activity against curli formation in E. coli biofilms [8].
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