Abstract
The provision of sufficient amounts of dietary proteins is central to muscle health as it ensures the supply of essential amino acids and stimulates protein synthesis. Older persons, in particular, are at high risk of insufficient protein ingestion. Furthermore, the current recommended dietary allowance for protein (0.8 g/kg/day) might be inadequate for maintaining muscle health in older adults, probably as a consequence of “anabolic resistance” in aged muscle. Older individuals therefore need to ingest a greater quantity of protein to maintain muscle function. The quality of protein ingested is also essential to promoting muscle health. Given the role of leucine as the master dietary regulator of muscle protein turnover, the ingestion of protein sources enriched with this essential amino acid, or its metabolite β-hydroxy β-methylbutyrate, is thought to offer the greatest benefit in terms of preservation of muscle mass and function in old age.
Highlights
An adequate intake of dietary proteins is vital to maintaining muscle mass as it ensures the provision of essential amino acids and stimulates protein synthesis
Skeletal muscle massofisProtein controlled by the interaction of many factors; it is indisputable that themass balance between by protein synthesis and breakdown an integral role in itthe
Some data suggest that resistance and aerobic exercise offers the greatest benefit to aged muscle when combined with a dietary protein intake that exceeds the current recommended dietary allowance (RDA) [59]
Summary
An adequate intake of dietary proteins is vital to maintaining muscle mass as it ensures the provision of essential amino acids and stimulates protein synthesis. This, along with the fact that high protein ingestion decreases the risk of perioperative complications [2,3], increases bone mineral density [4,5], and reduces rehabilitation time after an acute disease [6], highlights the importance of optimal protein ingestion in later life It is debated whether the current RDA for protein intake is truly sufficient to avoid major adverse events in older persons, especially in frail, critically ill patients [7]. MayThis clarify, atmay leastclarify, partially, be sufficient to increase mass in older malnourished older effect at the improvement in clinical outcomes observed in older hospitalized persons undergoing specific least partially, the improvement in clinical outcomes observed in older hospitalized persons protein supplementation regimens [7,13] This evidence centralemphasizes role of nutrition and in undergoing specific protein supplementation regimensemphasizes [7,13]. Of issues related to protein intake and eventually protein supplementation in old age must still be addressed
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