Abstract
The structural knowledge of protein is crucial in understanding its biological role. An effort is made to assign a fold to a given protein in a protein fold recognition problem. A computational Two-Layer Method (TLM) based on the Support Vector Machine (SVM), the Neural Network (NN) and the Decision Tree (C4.5) has been developed in this study for the assignment of a protein sequence to a folding class in SCOP. Prediction accuracy is measured on a dataset and the accuracy of the proposed method is very promising in comparison with other classification methods.
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