Protein expression of eIF4E and integrin αvβ6 in colon cancer can predict clinical significance, reveal their correlation and imply possible mechanism of interaction.

Zhengchuan Niu,Xueqing Zou,Shinichi Obo,Cheng Peng,Jiayong Wang,Qi Sun,Zhaobin He,Enyu Liu,Song Liu,Jun Niu,Benjia Liang,Shahbaz Muhammad,Weibo Niu

doi:10.1186/2045-3701-4-23

Abstract

BackgroundBoth eukaryotic translation initiation factor 4E (eIF4E) and integrin αvβ6 play an important role in the development and progression of cancer. The aim of this study was to investigate the expression of eIF4E and Integrin αvβ6, their clinical significance as well as the two proteins’ correlation in colonic carcinoma tissues.ResultsThe expression levels of eIF4E and integrin αvβ6 were analyzed in colon cancerous and paraneoplastic tissues of 138 cases via tissue microarray (TMA)- immunohistochemistry. And their clinical significance as well as the two proteins’ correlation was also investigated. The expression of eIF4E was significantly associated with clinical TNM stage (P = 0.009), while T stage (P = 0.011) and TNM stage (P = 0.012) were significantly associated with integrin αvβ6 expression. Moderately weak correlation exists between the two proteins (r =0.299, P <0.001). The survival analysis by Kaplan-Meier and Cox regression model showed that protein expression of high eIF4E and positive integrin αvβ6, as independent prognostic factors (RR = 2.417, P = 0.001 and RR = 2.393, P = 0.001), tended to have a significantly poorer 5-year survival rate (P = 0.013 and 0.025, respectively, the log-rank test).ConclusioneIF4E and Integrin αvβ6 were indicators of tumor’s progression and poor prognosis of patients with colon cancer. And the potential signaling loop involving them may provide a helpful therapeutic target in prevention and treatment of colon cancer.

Highlights

Colon cancer is one of the leading causes of cancer-related deaths worldwide
The aim of our present study was to explore the coexpression and clinical significance of eukaryotic initiation factor 4E (eIF4E) combined with integrin αvβ6 in colon cancer, which could provide a theoretical basis for further study of molecular mechanism in therapeutic intervention
The expression of integrin β6 and eIF4E in normal and neoplastic colon tissue For eIF4E cohort, 10 tumor cases could not be stained as negative expression, and positive rate was 92.8%, with 74 high expression (Figure 1, Table 1)

Summary

Introduction

With the improvement of current living standards and environmental degradation, its morbidity has been on the rise year by year [1] Both eIF4E and integrin αvβ can play important roles in the development and progression of colonic carcinoma [2,3,4]. About 10% of mRNAs. Integrins are a family of heterodimeric cell-adhesion molecules composed of two non-covalently bound transmembrane subunits (18 α-subunits and 8 β-subunits reported) [10]. Integrins are a family of heterodimeric cell-adhesion molecules composed of two non-covalently bound transmembrane subunits (18 α-subunits and 8 β-subunits reported) [10] These proteins collectively mediate cellular adhesion to extracellular matrix (ECM) and modulate cell proliferation, migration, invasion, and survival by activating intracellular signaling pathways [11]. The aim of this study was to investigate the expression of eIF4E and Integrin αvβ, their clinical significance as well as the two proteins’ correlation in colonic carcinoma tissues

Objectives

Methods

Results

Discussion

Conclusion