Abstract
Pattern sensor array, also called “chemical noses”, is an artificial olfactory based sensing array system. Here, a novel quantum dots (QDs)/fluorochrome fluorescence resonance energy transfer (FRET) based pattern sensing array was developed for the discrimination of different human serum proteins through target-triggered disassembly of noncovalent amphiphilic surfactant- polyelectrolyte nanomicelles. Firstly, seven noncovalent amphiphilic polymer nanomicelles were constructed with different surfactants and polyelectrolytes through supramolecular electrostatic assembling. The nanomicelles with apolar interiors can sequester QDs/Texasred-DHPE fluorochrome as FRET donor-acceptor pair. The nanomicelles would be disassembled in presence of different human serum proteins which could result in fluorescence attenuation of the fluorochrome and provide distinct fluorescence response patterns. By using this “chemical nose” strategy, five human serum proteins have been successfully discriminated via linear discriminate analysis. This study demonstrates the utility of the supramolecular disassembly to modulate the FRET process and presents a flexible pattern sensing platform for rapid identify and discrimination of biological proteins.
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