Protein crystallography in Australia.

Abstract

Protein crystallography is the study of the three-dimensional shapes of proteins at near atomic resolution. The field has provided a tremendous insight into the workings of numerous biological processes over the last few decades. The field is presently undergoing a massive worldwide expansion, not only in academic laboratories but also in the pharmaceutical industry. The main driving force for this expansion is the possibility of using the three-dimensional atomic structures of proteins to design lead drugs and to improve the action of existing drugs. This expansion in the field has been mirrored in Australia where the number of protein crystallography groups has more than trebled in the last five years. The work in the Protein Crystallography Unit at St Vincent's Institute of Medical Research has centered on the structural elucidation of membrane proteins and structure-based inhibitor studies of a protein family that attack certain anti-cancer drugs.