Abstract
AbstractCarbohydrates possess ideal properties for the synthesis of biocompatible nanocarriers. Therefore, hydroxyethyl starch was chosen as building material to produce biodegradable nanocarriers allowing the encapsulation of drugs. A mandatory feature for the successful application of nanocarriers in drug delivery is to avoid non‐specific uptake into macrophages. Todays’ gold standard is poly(ethylene glycol) (PEG) attached onto the surface of nanocarriers. As alternatives, we synthesize completely carbohydrate‐based nanocarriers by functionalizing the surface with different sugar derivatives (hydroxyethyl starch, dextran, or glucose) via copper‐free click reaction. Studying the interaction of sugar‐modified nanocarriers and plasma proteins indicates a strong enrichment of adsorbed ‘stealth’ proteins (clusterin) which are also identified on PEGylated nanocarriers. Cellular uptake studies proved that there is no unspecific interaction between carbohydrate‐ modified nanocarriers and phagocytic cells, herby underlining the stealth properties.
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