Abstract
In a continuing program of study of cervical carcinoma by special cell techniques, sections from cases of squamous metaplasia, atypical hyperplasia, carcinoma in situ, and invasive carcinoma of the cervix were stained with methylene blue and light green in a range of pH.Staining intensity of various cellular structures in normal and abnormal epithelium was recorded on an arbitrary scale.Proteins can be characterized by their staining reaction in a pH range. Binding with basic dye was more intense in an alkaline medium. Binding with an acid dye was more intense in an acid medium.Mitoses stained with basic dye in relatively acid medium.No difference was demonstrable between normal and cancer cells with this approach.Considering morphology and especially hyperchromatism, atypical hyperplasia shared the characteristics of invasive and in situ cancer, while metaplastic epithelium more closely resembled the character of normal epithelium.
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