Protein carbamylation associates with collagen in atherosclerotic plaque and impacts macrophage functions

Abstract

Background and Aims : Carbamylation is a post-translational protein modification increased in CKD patients as well as in late-stage atherosclerotic plaques in patients without CKD. Carbamylation was shown to cause pro-atherogenic alteration in plasma proteins and was significantly associated with increased mortality in CKD patients. However, the exact mechanisms and role of protein carbamylation in atherogenesis are not known.