Abstract
Malnutrition is often cited as a risk factor for lung infections, but the effects of malnutrition on the regional defense mechanisms in the lung are not clear. Severe protein-calorie malnutrition (PCM) impairs systemic immunity in humans and animals. 1 Feigin RD Interaction of infection and nutrition. in: Feigin RD Cherry JD Pediatric infectious diseases. Vol 1. WB Saunders, Philadelphia1981: 17-24 Google Scholar Cell-mediated immunity is profoundly effected, as indicated by abnormal cutaneous delayed hypersensitivity, 2 Good RA West A Fernandes G Nutritional modulation of immune responses. Fed Proc. 1980; 39: 3098-3104 PubMed Google Scholar impaired T-cell proliferative responses, 3 Chandra RK Cell-mediated immunity in nutritional imbalance. Fed Proc. 1980; 39: 3088-3092 PubMed Google Scholar and low thymic hormone levels. 4 Chandra RK Serum thymic hormone activity in protein-energy malnutrition. Clin Exp Immunol. 1979; 38: 228-230 PubMed Google Scholar Immunoglobulin turnover is usually reduced, and phagocyte chemotaxis and microbicidal activity are abnormal in some in vitro systems. 5 Douglas SD Schopfer K Phagocyte function in protein-calorie malnutrition. Clin Exp Immunol. 1974; 17: 121-128 PubMed Google Scholar
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