Abstract
BAX is a pro-apoptotic member of the BCL-2 protein family. During apoptosis in mammalian cells cytoplasmic BAX is activated and translocates to the outer mitochondrial membrane (OMM), where it participates in formation of an oligomeric pore capable of cytochrome c release. The biophysical mechanism of BAX activation is controversial and several in vitro and in vivo methods of its activation are known. One of the most commonly used in vitro methods is activation with non-ionic detergents, such as n-octylglucoside.
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