Abstract
Protein arrays are fast becoming established as a means to monitor protein expression levels and investigate protein interactions and function. They present particular technical demands that will need to be solved in order to achieve the maximum capability of efficient and sensitive protein analysis in the high throughput setting of functional genomics. The following resumé of some major issues around this new technology was made as the chairperson’s introduction to the workshop session on peptide and protein chips.
Highlights
Protein arrays are fast becoming established as a means to monitor protein expression levels and investigate protein interactions and function
Array formats are well established for global analysis of nucleic acids, as in the use of oligonucleotide and cDNA arrays for gene expression profiling
For information about the expression of the proteome, protein and peptide arrays are becoming major tools and the information that will be obtained from them in the future will complement that from DNA arrays
Summary
Protein arrays are fast becoming established as a means to monitor protein expression levels and investigate protein interactions and function. Array formats are well established for global analysis of nucleic acids, as in the use of oligonucleotide and cDNA arrays for gene expression profiling. For information about the expression of the proteome, protein and peptide arrays are becoming major tools and the information that will be obtained from them in the future will complement that from DNA arrays (some recent reviews are listed at the end of this article).
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