Protein and sugar contents, total antioxidant capacity, analgesic and antiulcer activities of quince fruit extract

Abstract

Cydonia oblonga belongs to the Rosaceae family, known in Algeria as sfarjel. It is a good source of secondary metabolites with antidiabetic, antihemolytic, and antiallergic effects. The present study was undertaken to estimate total proteins and sugar contents and in vitro antioxidant, analgesic, and gastroprotective activities of quince fruit ethanolic extract (QFEE). Proteins and sugar contents of QFEE were determined to be 0.06 ± 0.002 mg BSA E/ g of dry extract and 111.95±0.02 mg GE/g of dry extract, respectively. Using total antioxidant capacity (TAC), QFEE demonstrated a critical antioxidant activity with an IC50 value of 0.39±0.008 mg/ml. Oral administration of QFEE at 200 and 600 mg/kg doses to rats gave a dose-dependent gastroprotective effect in an ethanol model-induced ulcer, with protection percentages of 77.75 and 91.81 %, respectively. The same doses of extract had analgesic activities against acetic acidinduced abdominal contraction. According to these findings, quince extract is an essential source of antioxidant compounds that may have analgesic properties and shield the stomach from developing ulcers. Keywords: Cydonia oblonga Mill, Sugar content, protein content, Antioxidant activity, Analgesic, Ulcer.