Abstract
La0.7Sr0.3MnO3 (LSMO) is a mixed-valent room temperature ferromagnet with properties that are attractivefor their applicability in biomedicine. We report, for the first time, immobilization ofcommonly used biocompatible molecules on LSMO nanoparticles, namely bovine serumalbumin and dextran. The former was conjugated to LSMO using 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (CDI) as a coupling agent while the latter was used withoutany coupler. These bioconjugated nanoparticles exhibit several properties that suggest theirapplicability in the field of biomedicine, namely (a) no changes in the Curie temperature at∼360 K after conjugation with biomolecules, (b) rapid attainment of the desired temperature(48 °C) at low concentration (e.g. fluidized dextran-coated system at80 µg ml−1) upon exposure to 20 MHz radio-frequency, (c) extremely low cytotoxicity in skincarcinoma, human fibrosarcoma and neuroblastoma cell lines and (d) high stability of theLSMO system with negligible leaching of ionic manganese into the delivery medium,indicating their safety in possible human applications.
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