Protein adsorption on titanium oxide films synthesized by ion beam assisted deposition

Abstract

Titanium oxide films were prepared by ion beam assisted deposition (IBAD), where the films were synthesized by depositing titanium atoms and simultaneously bombarding with an Xe/sup +/ ion beam at an energy of 40 keV in an O/sub 2/ environment. The results show that titanium oxide films exhibit rutile type structure with [100] orientation. The surface energy of titanium oxide and titanium films prepared by IBAD were measured by the contact angle method. The results show that titanium oxide films with [100] orientation exhibit surface energy with dispersion component, /spl alpha/=5.79 (dyne/cm)/sup 1/2/ and polar component, /spl beta/=2.94 (dyne/cm)/sup 1/2/. The protein adsorption properties on low temperature isotropic pyrolytic carbon (LTI-carbon) and titanium oxide films with [100] orientation were studied by the radioisotope labeling method. The results show that there are less human fibrinogen (HFG) adsorbed on the surface of titanium oxide films between adsorbed HFG and proteins in solutions. In HSA/HFG (human fibrinogen) binary system, less HFG is adsorbed on titanium oxide films. The relationship between adsorption and surface energy was discussed. It can be concluded that the titanium oxide films with [100] orientation are better than those of LTI-carbon from a blood compatibility point of view.