Abstract
Medicinal plants are increasingly been investigated for potentials to provides active, safe and cost-effective alternative to synthetic antidiabetics. In the present study, hypoglycemic and hypolipidemic activities of crude methanol, hexane and ethylacetate fractions of Annona senegalensis (A. senegalensis) in alloxan-induced diabetic rats were evaluated. The extract and fractions of A. senegalensis were administered to alloxan (120 mg/kg bw) induced diabetic rats at doses of 100, 300 and 600 mg/kg bw. Glibenclamide (5 mg/kg bw) was used as the reference drug. All treatments were administered daily for 14 days through oral route with the aid of esophageal cannula. Effect of the treatments on blood glucose levels, body weight, packed cell volume (PCV) and lipid profiles were monitored. The crude extract had significantly (p 0.05) with the normal control rats but significantly (p < 0.05) lower than those treated with 600 mg/kg bw of the fractions and crude extract (100, 300 and 600 mg/kg bw). A. senegalensis carpel contains significant amount of phytochemicals with hypoglycemic reputation. The crude extract, ethylacetate and hexane fractions exhibited dose-dependent hypoglycemic and hypolipidemic activity in alloxan-induced diabetic rats.
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