Abstract
The development of autoimmune hemolytic anemia in NZB mice aged 2–3, 6–7, and 10–12 months is associated with decreased corticosterone and increased corticosteroid-binding globulin concentrations in the blood. An increase in the pool of free glucocorticoids induced by dexamethasone decelerates the autoimmune processes. (NZB×DBZ/2) F1 mice, which never develop the disease, are characterized by a high adrenal activity and a low blood level of corticosteroid-binding globulin. High level of free glucocorticoids is believed to prevent autoimmune reactions.
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