Abstract
Background: Chronic Obstructive Pulmonary Disease (COPD) is an inflammatory disease characterized by airflow obstruction, commonly present in smokers and subjects exposed to noxious particles product of biomass-burning smoke (BBS). Several association studies have identified single-nucleotide polymorphisms (SNP) in coding genes related to the heat shock proteins family-genes that codify the heat shock proteins (Hsp). Hsp accomplishes critical roles in regulating immune response, antigen-processing, eliminating protein aggregates and co-activating receptors. The presence of SNPs in these genes can lead to alterations in immune responses. We aimed to evaluate the association of SNPs in the HSP90 gene complex and COPD. Methods: We enrolled 1549 participants, divided into two comparison groups; 919 tobacco-smoking subjects (cases COPD-TS n = 294 and, controls SWOC n = 625) and 630 chronic exposed to BBS (cases COPD-BBS n = 186 and controls BBES n = 444). We genotyped 2 SNPs: the rs13296 in HSP90AB1 and rs2070908 in HSP90B1. Results: Through the dominant model (GC + CC), the rs2070908 is associated with decreased risk (p < 0.01, OR = 0.6) to suffer COPD among chronic exposed BBS subjects. We found an association between rs13296 GG genotype and lower risk (p = 0.01, OR = 0.22) to suffer severe COPD-TS forms in the severity analysis. Conclusions: single-nucleotide variants in the HSP90AB1 and HSP90B1 genes are associated with decreased COPD risk in subjects exposed to BBS and the most severe forms of COPD in tobacco-smoking subjects.
Highlights
Chronic Obstructive Pulmonary Disease (COPD) is a complex and multifactorial treatable disease characterized by a respiratory obstruction resulting from chronic exposure and inhalation of noxious particles produced by cigarette and/or biomass burning smoke [1].Other characteristics are chronic inflammation, sputum production, lung remodeling, emphysema and/or chronic bronchitis [2,3].Several immunological and lung cells characterize the inflammatory process, like macrophages, neutrophils and T-cells
We found an increased percentage of smoking women but an increased percentage of men diagnosed with COPD, COPD secondary to tobacco smoking (COPD-TS) present less BMI than controls
This study aims to describe the possible association between COPD and single nucleotide variants in HSP90 family genes in a Mexican mestizo population
Summary
Chronic Obstructive Pulmonary Disease (COPD) is a complex and multifactorial treatable disease characterized by a respiratory obstruction resulting from chronic exposure and inhalation of noxious particles produced by cigarette and/or biomass burning smoke [1]. Several immunological and lung cells characterize the inflammatory process, like macrophages, neutrophils and T-cells. Chronic Obstructive Pulmonary Disease (COPD) is an inflammatory disease characterized by airflow obstruction, commonly present in smokers and subjects exposed to noxious particles product of biomass-burning smoke (BBS). Results: Through the dominant model (GC + CC), the rs2070908 is associated with decreased risk (p < 0.01, OR = 0.6) to suffer COPD among chronic exposed BBS subjects. Conclusions: single-nucleotide variants in the HSP90AB1 and HSP90B1 genes are associated with decreased COPD risk in subjects exposed to BBS and the most severe forms of COPD in tobacco-smoking subjects
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