Abstract
1. The protective effect of chlorpromazine (CPZ) on the toxic effects of lead in mitochondrial functions was studied. 2. The findings indicate that CPZ at a concentration of 50μM protects heart mitochondria against lead-induced Ca 2+ uptake inhibition. 3. In addition, CPZ inhibits the drop of the transmembrane potential, as well as mitochondrial swelling as induced by 10 μM Pb 2+. 4. It is proposed that the protective effect of chlorpromazine can be due to its stabilizing action on biological membranes.
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