Abstract
It was reported earlier that administration of an acute dose of thioacetamide to rats produced changes in the rate of respiration, phosphate to oxygen ratio, and respiratory control ratio when either glutamate+malate or succinate were used as substrates (Padma and Setty, J. Clin. Biochem. Nutr., 22, 113-123). A significant decrease in the activities of electron transport chain enzymes was also observed. In the present study we report that administration of vitamin E prior to thioacetamide administration provided significant protection against the mitochondrial dysfunctions induced by thioacetamide. We speculate that the protective effect of vitamin E may be due to the ability of this vitamin to suppress elevated lipid peroxide levels in rats.
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