Abstract
Dichrocephala integrifola is a plant used empirically to manage hepatic affections. This study evaluates the preventive effects of the aqueous leave extract of Dichrocephala integrifolia on the blood and biochemical parameters in ethanol-induced hepato-nephrotoxicity in rats. To achieve this, the animals received different treatments (p.o): a normal control group and a negative group receiving respectively distilled water (10 mL/kg) and ethanol 40° (4 g/kg) with distilled water simultaneously; 3 other groups receiving the two doses of the plant extract or Simepar (100 mg/kg) and ethanol simultaneously. At the end of the experimental period, haematological and biochemical analyses were performed. The ingestion of ethanol provoked a decrease (at least p< 0.01) in the liver relative weight. The concentration of RBC, HGB, HCT; MCV; PLT; WBC; LYMP; NEUT; MONO dropped while the levels of WBC raised. Ethanol administration caused an (p< 0.001) increase in malondialdehyde even SOD and catalase activities whereas a decreased in nitrites and GSH was noticed. Transaminase levels, ALP, bilirubin and lipid profile were significantly altered associated with a micro-architectural disorganization materialized by hepatic cytolysis, diffuse infiltration of periportal inflammatory cells and dilation of sinusoids capillaries as well as an architectural disorganization of the kidney parenchyma with leukocyte infiltration. The extract protected the alteration of these parameters. It prevented the amplification of alterations induced by ethanol on hepatic and renal micro-architecture tissue whatever the doses. Data suggest the antioxidant and hepatoprotective activities of the extract, attesting the use of this extract in the treatment of liver affection in traditional medicine.
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