Protective mechanisms of radical scavengers vitamins C&E in an in-vivo pig model of pulmonary reperfusion injury

Abstract

PO TID x 10 wk) was used for comparison. Costs were based on average wholesale drug price and list price for serial PCR monitoring for 3 mo. Results: Each group consisted of 9 LTR. In the first 3 mo., primary CMV infxn occurred in 5/9 PRE and 1/9 GPX LTR. In each group, 1 case of primary CMV infxn occurred between 3-12 mo post-LT, resulting in 6 primary cases in the PRE and 2 in the GPX groups. Recurrent CMV infxn occurred in 4/6 PRE and 1/2 GPX LTR within the first yr post-LT. In the first 3 mo, 8 cases of HSV infxn occurred in the PRE LTR vs. none in the GPX LTR. In the PRE group, mean cost per pt for PCR monitoring and CMV Rx in the first 3 mo was $6339 vs. a mean of $5002 for GPX and Rx in the GPX group (p NS). Inclusion of HSV Rx costs increased the mean cost per pt to $6688 in the PRE group (p NS). Conclusions: Cost comparison of GPX vs. PRE is similar in the first post-LT yr and may favor GPX with a potential savings of $1686 per pt. Use of PRE without HSV prophylaxis led to increased non-CMV viral infxn within the first 3 mo post-LT. Resistant CMV infxn was not seen with GPX.