Abstract
To explain the active components of ZRC-CDs from the perspective of nanomaterials and investigate the potential mechanism for the treatment of diabetic liver injury, the structure, electron transfer properties, and elemental composition of ZRC-CDs were characterized. The protective effects of ZRC-CDs on the diabetic liver injury were demonstrated using the Alloxan-induced diabetic model. The ZRC-CDs are spherical, with a diameter ranging from 1.0–4.5 nm and a yield of 0.56%. The results showed that ZRC-CDs decreased the levels of blood glucose in diabetic mice and had a mitigating effect on elevated ALT and AST. More studies found that ZRC-CDs were able to decrease the levels of inflammatory cytokines and suppress the protein expression in related signaling pathways.
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