Abstract
The present study was conducted to determine the effect of albendazole alone or in combination with vitamin E on antioxidant activity and histopathological, changes on the liver and kidney. Following oral administration of albendazole of 0.25 mg/kg body weight and Vitamin E of 0.01 mg/kg body weight used for 21 successive days to broiler chicken, the experiment was done on fifteen broiler chickens divided into three groups: group one was non-treated, group two was treated with albendazole of 0.25 mg/kg body weight and group three was treated in combination with vitamin E of 0.01 mg/kg body weight. The blood sample and tissue were taken at the end of experiment 12 hrs after the last dose. The experimental result revealed that the significant decrease of liver enzymes caused by albendazole like serum Alanine Aminotransferase (ALP), Aspartate Aminotransferase (AST), Alkaline Phosphatase (ALT), when compared with the control group, the experimental result significant decrease in kidney parameters like urea creatinine level caused by albendazole and finally there was a significant increase in antioxidant enzymes activity like CAT, SOP, GPX and a significant decrease in MDA. Histopathology results in liver-treated animals with albendazole in combination with vitamin E showed dilated, congested Portal Blood Vessels (PBV, arrow), mild to moderate Biliary Proliferation (BP, arrow), portal Round Cells Aggregation (RCA, arrow), and focal Hepatocellular Degeneration (HCD, arrow). Histopathology results of kidney-treated animals with al- bendazole in combination with vitamin E showing a mild Per Tubular Edema (PTE arrow), focal Tubular Degeneration (TD arrow), Tubular Regeneration (TR, arrow), glomerular lobulation and atrophy (GL arrow), and beside interstitial cells aggregation (RCA arrow), H & EX 200. Therefore, vitamin E should be taken by albendazole to decrease its effect.
Highlights
Oxygen is an indispensable element for the sustenance of living beings and many biological systems
Effect of albendazole on RBCs, Hb, PCV, WBCs It was showed clearly from Table 1 that the oral administration of albendazole alone or in combination with Vitamin E in therapeutic dose for three week to broiler chicken induced significant increase in RBcs, Hb, PCV, WBcs level when compared with albendazole group (Table 1)
Effect of albendazole on serum AST, Alkaline Phosphatase (ALT), Alanine Phosphatase (ALP) It was clearly evident from Table 2 that the oral administration of albendazole alone or in combination with vitamin E in therapeutic dose for three week to broiler chicken induced significant decrease in AST, ATP, ALT level when compared with albendazole group (Table 2)
Summary
Oxygen is an indispensable element for the sustenance of living beings and many biological systems. By-products known as free radicals are created during this process These free radicals are beneficial in moderate levels but at higher concentrations can damage tissue by oxidative stress [1]. Antioxidants have been defined as substances that prevent that the genesis of Reactive Oxygen Species (ROS) or other oxidants, and repaired the damage they cause [2]. Vitamin E is an important antioxidant in biological systems that decreases the peroxidation of unstructural lipids by a chain-breaking Free Radical (FR), so it shares in the stability of cellular membranes [5]. Albendazole Sulfoxide, the active metabolite, causes selective degeneration of cytoplasmic microtubules in intestinal and tegmental cells of intestinal helminths and larva. This review covers key studies of the effect of albendazole in combination with vitamin E on antioxidant, tissue and blood samples were collected and the protective effect of vitamin E on the liver and kidney appreciated through measuring biochemical constituents is sera, such as serum creatinine level, liver biomarkers
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