Abstract
The effects of dimethyl sulfoxide (DMSO) and ethanol, which share an ability to scavenge free radicals, on ischemia/reperfusion-evoked injury to hippocampal CA1 pyramidal cells were evaluated in the Mongolian gerbil. Ischemia was induced by a 5 min period of bilateral common carotid artery occlusion followed by reperfusion for 5 days. Three groups of unanesthetized gerbils were injected intraperitoneally with either saline, DMSO (2.8 mmol/kg) or ethanol (2.0 mmol/kg) 30 min prior to ischemia. All three groups displayed significant increases in locomotor activity post-ischemia, with no differences between groups. The extent of CA1 pyramidal neuron loss was significantly reduced in the DMSO and ethanol treated gerbils. The results suggest that both agents may be useful as adjuvant therapies in the treatment of cerebral ischemia/reperfusion injury.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
