Abstract
BackgroundOxidative stress is a key factor that influences piglets’ health. Taurine plays an imperative role in keeping the biological system from damage. This study was conducted to investigate the protective effect of taurine against muscle injury due to the secondary effect of diquat toxicity.ResultsOur study found that taurine effectively and dose-dependently alleviated the diquat toxicity induced rise of feed/gain, with a concurrent improvement of carcass lean percentage. The plasma content of taurine was considerably increased in a dose-dependent manner. Consequently, dietary taurine efficiently improved the activity of plasma antioxidant enzymes. Furthermore, taurine attenuated muscle damage by restoring mitochondrial micromorphology, suppressing protein degradation and reducing the percentage of apoptotic cells in the skeletal muscle. Taurine supplementation also suppressed the genes expression levels of the antioxidant-, mitochondrial biogenesis-, and muscle atrophy-related genes in the skeletal muscle of piglets with oxidative stress.ConclusionsThese results showed that the dose of 0.60% taurine supplementation in the diet could attenuate skeletal muscle injury induced by diquat toxicity. It is suggested that taurine could be a potential nutritional intervention strategy to improve growth performance.
Highlights
Oxidative stress is a key factor that influences piglets’ health
After 3 d acclimatization, the piglets (9.15 ± 0.14 kg), 35 days old, were randomly allotted into 5 groups (n = 7/ treatment): (1) control piglets (CON); (2) diquattreated piglets (DIQ); (3) piglets supplemented with 0.15% taurine and treated with diquat (LT); (4) piglets supplemented with 0.30% taurine and treated with diquat (MT);(5) piglets supplemented with 0.60% taurine and treated with diquat (HT)
Compared with DIQ group, no difference was observed in initial weight, final weight, average daily feed intake (ADFI) and average daily gain (ADG) in taurine treatment (LT, MT, and HT), the F/G ratio was significantly decreased and the carcass lean percentage was significantly increased in a doseresponsive manner (P < 0.05)
Summary
Oxidative stress is a key factor that influences piglets’ health. Taurine plays an imperative role in keeping the biological system from damage. Diquat (1,1′-ethylene-2,2′-dipyridyliumdibromide monohydrate), a commonly applied bipyridyl herbicide and a potent pro-oxidant, is widely used to induce oxidative stress in different animal models [5, 11,12,13,14]. These models of oxidative stress can induce similar in increase generation of reactive oxygen species (ROS) and damages in muscle tissue. Recent findings support the idea that diquat can induce oxidative stress and depress animals’ growth performance [5, 11]. Diquat-induce damage in skeletal muscle remains unclear
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