Abstract

BackgroundOxidative damage has been proposed as a possible mechanism involved in lead toxicity, specially affecting the liver and kidney. Previous studies have shown the antioxidant effect of Spirulina maxima in several experimental models of oxidative stress. The current study was carried out to evaluate the antioxidant activity of Spirulina maxima against lead acetate-induced hyperlipidemia and oxidative damage in the liver and kidney of male rats. Control animals were fed on a standard diet and did not receive lead acetate (Control group). Experimental animals were fed on a standard laboratory diet with or without Spirulina maxima 5% in the standard laboratory diet and treated with three doses of lead acetate (25 mg each/weekly, intraperitoneal injection) (lead acetate with Spirulina, and lead acetate without Spirulina groups).ResultsThe results showed that Spirulina maxima prevented the lead acetate-induced significant changes on plasma and liver lipid levels and on the antioxidant status of the liver and kidney. On the other hand, Spirulina maxima succeeded to improve the biochemical parameters of the liver and kidney towards the normal values of the Control group.ConclusionsIt was concluded that Spirulina maxima has protective effects on lead acetate-induced damage, and that the effects are associated with the antioxidant effect of Spirulina.

Highlights

  • Oxidative damage has been proposed as a possible mechanism involved in lead toxicity, specially affecting the liver and kidney

  • Body weight of rats The effect of Spirulina maxima (Sm) and lead acetate on animal body weight gain in the different treatments revealed that lead acetate (LAwS) alone significantly decreased the body weight (p < 0.05)

  • The results showed that the Lead acetate (LA) significantly increased plasma levels of CT and TAG in the LAwS group compared with the other groups

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Summary

Introduction

Oxidative damage has been proposed as a possible mechanism involved in lead toxicity, specially affecting the liver and kidney. The current study was carried out to evaluate the antioxidant activity of Spirulina maxima against lead acetate-induced hyperlipidemia and oxidative damage in the liver and kidney of male rats. Lead is one of the most useful metals, it is one of the most toxic ones [3]. Both occupational and environmental exposures remain a serious problem in many developing and industrializing countries [4]. Lead produces oxidative damage in the kidney as evidenced by enhancing lipid peroxidation (LIP) [11,12]

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