Protective effects of sesamol against cisplatin-induced nephrotoxicity in rats: A mechanistic approach

Abstract

BackgroundAcute renal failure specifically denotes tubular necrosis due to induced by ischemic injury or drugs, resulting in electrolyte imbalance along with changes in hormonal levels in renal system, causing accumulation of nitrogenous waste in the kidneys. ObjectiveTo explore the role and mechanism of sesamol as renoprotective using cisplatin mediated nephrotoxicity in male Wistar rats. MethodIn male wistar rats, a single dose of 5 mg per kg of body weight, i.p cisplatin was used to induce nephrotoxicity. Renoprotective effect of sesamol was evaluated by analyzing blood, urine, oxidative stress markers and tissue histology. ResultPresent study shows that cisplatin confirms the nephrotoxicity by modifying the urinary, blood and inflammatory parameters in contrast to the vehicle control group. Sesamol at dose levels of 50 and 100 mg/kg body weight, p.o. significantly & dose dependently reverses the changes. Nephroprotective effect of sesamol was abolished by PPAR-γ inhibitor, BADGE (30 mg/kg, i.p.) in rats. ConclusionOur study clearly indicates the nephroprotective activity of sesamol by PPAR-γ agonism against cisplatin-induced nephrotoxicity in rats.