Abstract
Chromium is a toxic metal implicated in human diseases. This study was focused on investigating the possible protective effect of Se against K 2Cr 2O 7. Female Wistar rats, used in this study, were divided into four groups of six animals each: group I served as control which received standard diet; group II received orally only K 2Cr 2O 7 (700 ppm equivalent to 67 mg/kg bw); group III received both K 2Cr 2O 7 and Se (0.5 mg/kg of diet); group IV received Se (0.5 mg Na 2SeO 3/kg of diet). The exposure of rats to K 2Cr 2O 7 for 21 days provoked renal damages with a significant increase in kidney malondialdehyde, superoxide dismutase, plasma creatinine, and uric acid levels, while catalase, glutathione peroxidase, non-protein thiol, Metallothionein and plasma urea levels decreased. Coadministration of Se in the diet of chromium-treated group improved malondialdehyde, renal biomarkers levels and antioxidant enzyme activities. Kidney histological studies confirmed biochemical parameters and the beneficial role of selenium.
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