Abstract
Inorganic arsenic is a potent carcinogen and environmental pollutant. More than one hundred million people are reported to be exposed to elevated concentrations of arsenic mainly via drinking water. Essential trace elements can affect toxicity of metals by interacting with metals at the primary site of action and can also modify the body's response to toxic metals by altering their metabolism and transport. This study investigates the effects of concomitant administration of selenium, magnesium, and calcium with arsenic on blood biochemistry and oxidative stress. Selenium was the most effective in reducing arsenic-induced inhibition of blood delta-aminolevulinic acid dehydratase (ALAD) activity and liver oxidative stress. Calcium and magnesium also showed favourable effects on haematological and other biochemical parameters. Because selenium was the most effective, it should be added to chelation therapy to achieve the best protective effects against arsenic poisoning in humans.
Highlights
Inorganic arsenic is a potent carcinogen and environmental pollutant
The aim of this study was to see the effects of selenium, magnesium, or calcium co-administered with arsenic on biochemical indicators such as haem synthesis, blood, liver, and kidney oxidative stress, liver injury, and blood and tissue arsenic concentration in male rats
This study has investigated the effects of arsenic on biochemical parameters indicative of changes in haeme biosynthesis, liver and kidney oxidative stress, and liver damage, and has investigated the ability of Animal group Negative control As As+Se As+Mg As+Ca
Summary
Inorganic arsenic is a potent carcinogen and environmental pollutant. More than one hundred million people are reported to be exposed to elevated concentrations of arsenic mainly via drinking water. Arsenic (As) is a widespread environmental toxicant that may cause neuropathy, skin lesions, vascular lesions, and cancer in chronic exposure [1, 2] It exists in the inorganic and organic form and in different oxidation states (-3, 0, +3, +5). Glutathione (GSH) acts as a nucleophilic scavenger of numerous toxic compounds and their metabolites via enzymatic and chemical mechanisms and plays an important role in protecting against oxidative damage caused by ROS [9, 10]. The aim of this study was to see the effects of selenium, magnesium, or calcium co-administered with arsenic on biochemical indicators such as haem synthesis, blood, liver, and kidney oxidative stress, liver injury, and blood and tissue arsenic concentration in male rats
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